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The success of semaglutide has also intensified the pharmaceutical race other companies are developing their own GLP-1 approaches (for instance, Eli Lillys oral non-peptide GLP-1 agonist orforglipron is in late-stage trials, expected to file for FDA approval in 2026)

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"We wanted to make sure that we stayed on message: This was a temporary thing and the goal is to taper off the drugs and [not to] stay on GLP-1s permanently," says a former Calibrate health coach, who worked with several hundred of the company's customers during her time at the company, but asked for anonymity in order to discuss her former employer

Patients who maintain a regular exercise routine, manage their stress levels, and get enough sleep are more likely to see sustained results